Iridocorneal Endothelial Syndrome (ICE)
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Iridocorneal endothelial syndrome (ICE) is more common in women and usually develops between ages 30-50. ICE has three main features:
- Visible changes in the iris, the colored part of the eye
- Swelling of the cornea
- Glaucoma
ICE is usually present in only one eye. It is caused by the movement of endothelial cells from the cornea to the iris. This loss of cells from the cornea leads to corneal swelling and distortion of the iris and pupil. This cell movement also blocks the fluid outflow channels of the eye, which causes glaucoma.
There is no treatment to stop the progression of ICE, but the glaucoma is treatable. If the cornea becomes so swollen that vision is significantly impaired, a corneal transplant may be necessary.
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